A Team Dedicated to Finding New Ways to Treat Endocrine System Diseases

Mike Grey

Executive Chairman, Independent

Mike Grey is Executive Chairman of the Spruce Biosciences Board of Directors. He also serves as venture partner at Pappas Ventures.  Previously he founded and was president and chief executive officer at Lumena Pharmaceuticals, Inc., a company developing treatments for pediatric and adult orphan diseases, until its acquisition by Shire plc. Mike has 40 years of experience in the pharmaceutical and biotechnology industries, and has held senior positions at a number of companies, including president and chief executive officer of Auspex Pharmaceuticals, Inc., president and chief executive officer of SGX Pharmaceuticals, Inc., which was acquired by Eli Lilly in 2008, president and chief executive officer of Trega Biosciences, Inc., which was acquired by Lion Bioscience in 2001, and president of BioChem Therapeutic Inc. For approximately 20 years, Mike served in various roles with Glaxo, Inc. and Glaxo Holdings plc, culminating in his position as vice president, corporate development and head of international licensing. Mike serves on the board of directors of Balance Therapeutics, Inc., Amplyx Pharmaceuticals, BioMarin Pharmaceutical Inc., Biothera Pharmaceutical, Inc., Horizon Pharma plc, and Mirati Therapeutics, Inc.

Alexis Howerton, PhD

Chief Executive Officer

Dr. Howerton has served as the CEO of Spruce Biosciences since inception. Prior to founding Spruce, Dr. Howerton was a postdoctoral scholar at Stanford University, where she worked in clinical biomarker development to drive patient-centric targeted therapeutics. Dr. Howerton received her PhD in neuroscience from the University of Pennsylvania School of Medicine, where she received additional training in clinical research, epidemiology, and biostatistics. She earned her undergraduate degree in neurobiology from Macalester College, where she graduated with honors.

Michael Huang, MD

Chief Medical Officer

Dr. Huang has over a decade of clinical research experience spanning all phases of drug development. Prior to joining Spruce, Dr. Huang’s leadership in drug development resulted in several successful drug approvals across an array of therapeutic areas including indications in rare (orphan) diseases. Most recently, Dr. Huang served as Vice President of Clinical Development at Regulus Therapeutics and Vice President of Clinical Development at Auspex Pharmaceuticals, until its acquisition by Teva. Earlier in this career, Dr. Huang held positions of increasing responsibility at Spectrum Pharmaceuticals and Santarus until its acquisition by Salix. Dr. Huang holds an undergraduate degree from the University of California, Berkeley, a medical doctorate degree from the Chicago Medical School, and post-graduate medical training at the University of California, Irvine – Long Beach Memorial Medical Center.

Kathy Powell, MS

Quality & CMC

Ms. Powell joins Spruce with over 28 years of experience in Chemistry, Manufacturing, and Controls (CMC) and Quality management.  She has held related management positions at Genentech, Covance Biotechnology Services, Inc. and Raptor Pharmaceutical, Inc.  In a consulting capacity, Kathy has served as the acting head of CMC and Quality functions in over ten organizations covering development through commercial manufacturing operations.

 

Lisa Koch-Hulle, RAC

Regulatory Affairs

Ms. Koch-Hulle has more than 25 years of regulatory affairs experience across multiple therapeutic areas and all stages of drug development, with approximately 15 years at the senior management level.  Prior to Spruce, Ms. Koch-Hulle most recently held the position of Vice President of Regulatory Affairs and Clinical Operations at Light Sciences Oncology, and prior to that held the same position at La Jolla Pharmaceutical Company.  Ms. Koch-Hulle has also served as a regulatory consultant to the pharmaceutical industry.  Ms. Koch-Hulle holds regulatory certifications in US, European, and Global regulatory affairs, and is a former Chair of the RAPS European Certification Committee.

Elliot Offman, BSc Pharm, MSc, PhD

Pharmacometrics & Clinical Pharmacology

Dr. Offman is a consultant with Certara supporting Spruce Biosciences with strategic clinical pharmacology and pharmacometrics development and analysis.  Prior to joining Spruce, Dr. Offman oversaw biopharmaceutics and scientific affairs for Genpharm. As a clinical pharmacologist, he supported development programs at Santarus and Auspex.  Prior to joining Certara, Dr. Offman was responsible for clinical pharmacology and pharmacometrics at Celerion, responsible for study design, data analysis and interpretation for clinical pharmacology studies including first-in-human, drug-drug interactions, mass balance and special population trials. Dr. Offman obtained his PhD at the University of Waterloo in model-based drug development, completed a residency in clinical pharmacy and received his pharmacy license at the London Healthy Sciences Centre, and obtained an MSc from Western University in Ontario, Canada.

Now Enrolling Patients for

Congenital Adrenal Hyperplasia Clinical Trials 2018

If you are an adult with a genetic diagnosis of classic Congenital Adrenal Hyperplasia, you may be eligible to participate in a Phase 2 clinical trial for a new therapy for CAH. To be notified when a site opens near you, sign up for our mailing list.

Our Phase 2 program has active sites in San Diego, CA, Orange, CA, Las Vegas, NV, Atlanta, GA, Indianapolis, IN, Minneapolis, MN, Melbourne, FL.

Learn More

Spruce Biosciences is a clinical-stage biotechnology company developing novel therapies for rare endocrine disorders. We are leveraging our extensive expertise in endocrinology and orphan drug development to meet the significant unmet need of patients suffering from these diseases. We are committed to transforming the quality of life for patients who have been underserved by scientific innovation.